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Anti-cold immune cells can deal with nCoV

Scientists have found a lot of evidence that the corona virus that causes colds stores “memories” in the immune system, helping the body to fight Covid-19.

nCoV when viewed under a microscope. Photo: SCMP.

Two independent studies by US and German scientists showed that some immune cells that protect the body from colds often react when exposed to COV. Although no studies have indicated whether the available memory of immune cells influence the outcome of Covid-19 treatment, both groups concluded that evidence of cross immunity could explain why some people respond more strongly to this disease. Understanding how the human immune system fights Covid-19 could help researchers design vaccines and drugs to treat disease.

Research published early August in the journal Nature by German scientists found that one in three volunteers who have never been previously infected with nCoV, has an immune cell called T cells that aid in virus identification. . “This finding has many important epidemiological implications for public immunity and Covid-19 prevention planning,” said the team at Charite University Hospital in Berlin and the Max Planck Institute of Molecular Genetics, said.

The researchers examined how T-cells responded to segments of the nCoV gene synthesized in the blood of 68 healthy people, and looked at a similar immune response in 18 infected patients. T cells assist in promoting immune response from other cells and antibodies, but their role in combating nCoV is not well understood. Researcher Leif Erik Sander at Charite Hospital said they are more likely to have protective effects. “In this case, a recent cold infection can lead to a less severe Covid-19 symptom,” Sander explained.

A second study published in Science on August 4 by American scientists determined the structural similarity between nCoV and corona virus that causes colds that cause T cells to react. This study provides direct molecular evidence that proves T cells can recognize the similarities between nCoV and the cold-causing corona virus, according to study co-author Alessandro Sette at the La Immunology Institute. Jolla in America.

However, Ashley St. John, an immunologist and associate professor at the National University of Singapore School of Medicine, says more large-scale studies are needed to understand the cross-action of immune cells. Joanna Kirman, associate professor of microbiology and immunology at the University of Otago, New Zealand, also emphasized that it is not clear whether the T-cell cross-reactivity impacts infection control.

(According to SCMP)

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